Anti Aging - The Miracle Cure for Aging
- josephplatt1979
- May 25, 2023
- 8 min read
Nicotinamide Mononucleotide (NMN) - The Miracle Cure for Aging
Imagine being able to put a stop to aging, pull it back or even slow it down? How about having the energy of a 20-year-old in your 50s? Or turning back the hormonal clock, anti aging and reversing menopause? These wishes are not so far off anymore! In fact, scientists have been studying a particular molecule in the labs and have now found an aging elixir. If you have heard about NMN and want to know more about what it can do for you and how to get the best results, read on!
What is NMN and how does it relate to aging and longevity?
It all happened about 20 years ago at M.I.T (Massachusetts Institute of Technology) when Leonard Guarente, a biology professor, and a team of other scientists discovered SIRT1 genes (Sirtuins) in yeast.
Sirtuins control aging - seven of them are found in humans and five in yeast.
Essentially, they protect all organisms on the planet, including humans, from deterioration and disease. They work amongst many cellular pathways that control cell death, turn anti-aging genes on and off, help repair DNA, and regulate metabolism. SIRT 1 is one of the four longevity pathways.
When more of these genes were put in organisms, the organisms’ lifespans extended by 5 to 20 percent. It was with this discovery that scientists began mimicking the genes using molecules. One of the molecules they used was NMN and the other, resveratrol.
Nicotinamide mononucleotide (NMN) is a substance made by our bodies that are converted into nicotine adenine dinucleotide (NAD). NAD is required by all cells to provide energy and regulate critical survival functions. NAD cannot be readily absorbed into the body but must be manufactured from precursors like NMN, tryptophan, and nicotinamide.
NAD is a powerful and essential molecule that is found in every cell of the body. Believe it or not, if NAD levels in your body drop to zero, you’d be dead in about 30 seconds.
Also, and probably the most important when it comes to longevity and the fight against aging, NAD+ plays a crucial role in activating Sirtuins. As a matter of fact, without NAD, the SIRT1 genes can’t work and perform their role of protecting our bodies from deterioration and disease.
Unfortunately, as we age, the levels of NAD+ fall. By the time we are 50 years old, for most of us, our NAD+ levels are about half of what they were when we were 20. This decrease in NAD interferes with SIRT1’s ability to defend our bodies and slow down the aging process.
IS NMN BETTER THAN NAD?
For many years, it was thought that the NAD molecules were too large to be taken directly and needed to be raised using a precursor such as NMN. Recently, it has been found that NAD can cross the blood-brain barrier and to reach the hypothalamus if taken sublingually.
It can boost NAD+ levels in this gland which will benefit the entire body because it controls the metabolism. It’s can also be a potential supplement to help those who have metabolic disorders because of decreased NAD+ levels in the hypothalamus.
NMN, on the other hand, elevates NAD+ levels in cells throughout the body and is a better supplement to take to boost your overall NAD+ levels and slow aging.
ANTI-AGING BENEFITS OF NMN
NMN has been at the forefront in studies aimed at understanding and reversing the aging process. The role of NMN as a precursor to NAD+ is critical in boosting longevity, but here are two more ways NMN fights aging:
NMN suppresses age-related weight gain
As people age, they gain weight. In a 2016 study, it was found that subjects given NMN saw their fat mass decrease and lean mass increase. By supplementing with NMN, you can lose weight and build muscle—two powerful ways to improve muscle health and look and feel younger!
NMN boosts energy metabolism
By mediating the synthesis of NAD, NMN helps in breaking the nutrients into energy, powering important cell functions and reducing oxidative stress. These biochemical processes slow down and potentially halt the aging process. NMN not only boosts your energy but helps in repairing your cells!
NMN and UV damage
UV light is the number one cause of premature skin aging. NMN is a powerful antioxidant that scavenges up free radicals.
Studies in animals suggest that NMN help reduce free radicals produced by the sun that attack our cells and destroy our collagen and elastin. Collagen and elastin destruction leads to wrinkles and sagging skin.
Inconclusive is the evidence around NMN for cancer protection. On one hand, some animal studies suggest that NMN may help repair the damage that UV light causes to our DNA, which may lead to skin cancer formation.
WHAT IS NMN GOOD FOR?
It’s almost, if not totally impossible, to discuss NMN benefits without looking at the longevity pathways. There are four main longevity pathways identified in organisms including humans:
When activated, each of these pathways regulates lifespan and aging. NMN together with resveratrol work through the SIRT1 Pathway to stop or backpedal the effects of aging.
Below are the specific benefits of NMN in activating the body’s defences against aging.
NMN boosts energy supply in aging cells
Cells take in and process fuel to power their functions. As you age they lose this ability, forcing them into a condition known as cellular senescence or biological aging that comes with other detrimental effects.
Previously, NAD+ which is a key element of the cell’s fuel supply was thought to be the only route through which NMN can contribute to cell energy. However, a ground-breaking Washington University School of Medicine study published in the Nature Metabolism journal shows that NMN can be delivered directly into cells without conversion to NAD+.
This direct and faster delivery is possible with the help of a mystery transporter protein called Slc12a8. Another interesting discovery is that Slc12a8 is automatically dialled up by cells when NAD+ levels fall.
This means that supplementing with NMN gives your cells a much quicker path to refuel and promotes cell division and growth.
NMN helps in fighting metabolic diseases
As you age, conditions such as diabetes, obesity, dyslipidaemia, and non-alcoholic fatty liver disease (NAFLD) become prevalent. They are caused by a reduction in NAD+ levels. NMN works through the salvage pathway to boost the levels of NAD+ thereby ameliorating these and other metabolic diseases.
Imagine being 90 and disease-free. You can literally run around with your grandchildren like a 50-year-old! It is possible to achieve this level of youthfulness with NMN supplements.
NMN reactivates faltering blood flow
According to a 2018 study published in the Cell journal, aging mice with a compromised blood flow experienced a reactivation of their blood flow after taking NMN.
The researchers, led by Dr. David Sinclair, a co-director at Paul F. Glenn center at Harvard Medical School, found that as the body ages, the number and functions of endothelial cells (ECs) lining the blood vessels decline.
This capillary decline affects the supply of nutrients, oxygen, exchange of heat, and removal of waste products. If nothing is done to stop or reverse this loss, it accelerates the aging process and along with it comes age-related complications.
Have you found yourself struggling to exercise or wished you could last longer on a treadmill? Well, this is the reason behind the decline in strength and endurance you are experiencing as you age.
However, all is not lost! The study found that NAD+ precursors such as NMN and nicotinamide riboside (NR) working through the Sirtuin Pathway, can help restore the capacity of endothelial cells to form new blood vessels.
There you go, another reason to boost your NAD+ levels with NMN supplements!
Most probably this supplement is already on the watch list of most professional sports teams in America because of its ability to enhance performance by boosting the blood flow. We all hope they get it fast before the World Anti-Doping Agency (WADA) comes knocking!
"By the turn of the next century, a person who is 122 on the day of his or her death may be said to have lived a full, though not particularly long, life."
- BIOLOGIST DAVID SINCLAIR
CAN NMN REVERSE MENOPAUSE?
Dr Sinclair and his team initially focused their research on male subjects. However, when they started adding NMN to the water of aged post-menopausal female subjects, they noticed an interesting observation: they were able to reproduce for longer. When they studied the egg cells, they found that the DNA and chromosomes were normalized to that of the equivalent of a younger egg cell, and they were able to reproduce once more.
The results of their research indicate that NMN may be effective in slowing down and possibly even reversing menopause. It also holds great potential as a fertility treatment that is non-invasive.
DOES NMN HAVE ANY SIDE EFFECTS?
Scientists have researched NMN extensively. To date, there is no evidence that shows any negative side effects.
Dr. David Sinclair named one of the 100 most influential people in the world by Time Magazine, has been taking NMN supplements for years with friends in the aging industry. To date, he hasn’t experienced any side effects except when NMN is stored in hot/warm temperatures. When this happens, NMN degrades to Nicotinamide poison your body. Therefore, it’s very important to always store your NMN in a cool climate or ideally in a fridge.
If you notice symptoms of reduced effectiveness of NMN such as decreased sleep quality and reduced memory, it might be beneficial to cycle off NMN for one week to allow the body the occasional break.
If you’d like to listen to a podcast where he talks about his research and NMN, you can listen to it here: The Joe Rogan Experience — David Sinclair, Ph.D.
IS NMN SAFE?
A human trial was recently conducted out of Japan. The purpose of the trial was to determine if NMN was safe to take. NMN was administered to 10 healthy men. Dosages of 100, 250, and 500 mg NMN were given. The single oral administrations of NMN did not cause any significant clinical symptoms or changes in main biomarkers like heart rate, blood pressure, oxygen saturation, and body temperature. The trial helps to confirm that, in general, NMN is safe and well-tolerated; to that end, the trial can be considered a success.
HOW MUCH NMN SHOULD YOU TAKE DAILY?
So, what is the recommended dose of NMN?
We recommend the following daily dosages for NMN based on customer feedback based on age.
Another method to calculate the required NMN dose is to take your weight is based on the following study. Given that 100 mg/kg/day of NMN was able to mitigate most age-associated physiological declines in mice, an equivalent surface area dose for humans would be ~8 mg/kg/day.
As an example, if you weigh:
WHEN TO TAKE NMN
We recommend you take NMN on an empty stomach first thing in the morning even if you’re fasting. Don’t mix the sublingual NMN with juice or water, it will reduce the bioavailability. For maximum effectiveness, take it directly under the tongue as directed.
Also, to improve your NAD+ levels, you can take the delayed-release NMN capsules with a Sit-in Activator such as a Resveratrol with a full-fat yogurt which helps the bioavailability of Resveratrol.
WHY SUPPLEMENT WITH NMN?
As we have shown, NMN plays a crucial role in creating NAD+. When we have high levels of NAD+ in our bodies, cellular energy increases which becomes the fuel of life—powering every organ and cell in our bodies and protecting us from DNA damage. NAD+ also activates Sirtuins which are essential in increasing our life expectancy and slowing down the aging process.
Supplementing with NMN directly increases the levels of NAD+ in our bodies, which counteracts the natural decline that occurs as we age. Research has shown that by supplementing with NMN, the NAD+ levels in older people can be raised to that of a 20-year-old!
HOW LONG DOES IT TAKE TO SEE EFFECTS OF NMN?
Youth & Earth’s NMN increases the level of NMN in your body within minutes, while NAD+ levels are increased within 60 minutes. However, for the NAD+ to start rejuvenating your cells, it generally takes a few weeks.
Most users report that they feel younger and healthier within 2 to 3 weeks. The complete benefits of NMN can be felt after a few months of use—but you’ll already feel the difference within a few weeks!
So, if you want to experience the transforming effects of the Youth Earth's NMN, you now have a unique chance to do so. And the best part? You do not have to take any risk. Youth Earth's NMN is covered by a satisfaction guarantee. This means that because they are so sure you will love their NMN, they are willing to provide you with a guarantee.
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